| Overview *Embryonic stem cells
*Fetal tissue experiment
failures
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*US/overseas News
*Links
*Research adult v embryonic stem cells *Cartoonists' view *Journal articles *Quotable quotes |
There are two sources for stem cells - adult and embyro.
"Adult" stem cells can come from a newborn, child or adult, even the patient's
own body.
Their use does not kill anyone and so is completely ethical.
Many cures have already been attributed to use of adult stem cells.
So far, all the "claims" made for use of embryonic stem cells are at best
overpublicised "promises", hoped for results that have not been achieved.
Embryonic stem cells are cell tissue extracted
from human embryos. These cells can then be teased into providing an endless
supply of healthy cells for unhealthy organs. The cells have been 'convinced'
by researchers to grow into nerve cells, skin cells, heart cells - in fact
potentially all 210 kinds of human cells can be grown from foetal stem cells.
Sources of these are: from abandoned embryos in IVF clinics, and 5-9 week
old aborted foetuses. It is not right for big humans to cannibalise parts
of weak little humans to benefit themselves. It must be remembered that
stem cell extraction kills the embryo the cells come from or is a direct
side-product of abortion! Embryos are being used as sub-human commodities,
as disposable laboratory material, corrupting our respect for human life.
It was wrong to produce so many excess IVF frozen embryos, and using them
is no better than the Nazi experiments on people who were "going to die anyway".
Embryonic stem cell extraction is the same as removing organs from someone
killed for the express purpose of harvesting their body parts - an act that
is intrinsically evil, regardless of the intent to do good to someone else
as a result.
"Embryonic stem cells cannot be used directly. They are likely to be
rejected, and have been shown to be prone to produce tumours. Transplanting
incompletely differentiated cells runs the serious risk of introducing
cells with abnormal properties into patients. This is of particular concern
in light of the enormous tumor–forming potential of embryonic stem cells.
If only one out of a million transplanted cells somehow failed to receive
the correct signals for differentiation, patients could be given a small
number of fully undifferentiated embryonic stem cells as part of a therapeutic
treatment. Even in very small numbers, embryonic stem cells produce teratomas,
rapid growing and frequently lethal tumors. (Indeed, formation of such
tumors in animals is one of the scientific assays for the "multipotency"
of embryonic stem cells.) No currently available level of quality control
would be sufficient to guarantee that we could prevent this very real and
horrific possibility."
"The Basics About Stem Cells" by Maureen L. Condic First
Things 119 (January 2002): 30-34.
Quote on experiments on embryos by Geneticist Jerome Lejeune:
"To accept the fact that after fertilisation has taken place, a new human
being comes into being, is no longer a matter of taste or of opinion. The
human nature of the human being from conception to old age is not a metaphysical
contention, it is plain experimental evidence...Why we should not experiment
on human beings is very simple: from all the genetic laws that we have tried
to summarise, we are entirely convinced that every embryo is, by itself,
a human being...I am a doctor. I have sworn the Hippocratic Oath which means
that we are at the service of our patients, that we will never procure something
which can kill an embryo... People would not have faith in a doctor who is
trying to heal and sometimes to kill with the other hand." Evidence to Senate
Select Committee on Human Embryo Experimentation.
BAD NEWS: NIH CONSIDERS NEW FETAL TISSUE
RESEARCH GUIDELINES
WASHINGTON, D.C., JAN 30,2000 (ZENIT).- The National Institute of Health
(NIH) has issued new guidelines that would change U.S. policy toward
fetal tissue research. The guidelines include standards for
harvesting "stem cells" from living embryos, a procedure that kills the unborn
child. Previously, the destruction of live embryos for federal
research
was not permitted. The children that will be used are "spare" embryos
from fertility clinics that are "in excess of clinical need."
Scientists say the dozen or so existing stem cell cultures are not enough
for their needs, and estimate they will need hundreds of cell lines ( i.e..
drawn from hundreds of different embryos) to work on.
The Nuremberg Code, adopted in response to the horrors of Nazi "research,"
states: "There shall be no experimentation on a human being when it is known
ahead of time that the research will kill that human being." That is precisely
what "therapeutic cloning" does, and that is why we must oppose it.
Pro-life leaders point out that the same research could be done
with umbilical cord blood, adult stem cells, or placental cells.
With the news that using adult stem cells may be more fruitful in treating
disease than embryonic stem cells, there seems little need for this destruction
of tiny humans for scientific research. The adult cells can be taken from
the adult patient, and returned after treatment, thus removing the possibility
of rejection. (See the international journal Science 2 April 1999).
**
UCLA scientists have figured out a way to harvest stem cells from fat
removed during cosmetic surgery. Researchers at University of California
succeeded in converting adult stem cells from human fat tissue into bone,
muscle and cartilage cells. (The Times, April 10, 2001)
**
Scientists have turned skin cells from cows into beating heart cells that
could be used to repair a damaged heart. If perfected, it would sidestep therapeutic
cloning, which involves the creation and destruction of human embryos to
make tissue for repairs to the body.
In Neuroscience magazine August 2000 researchers reported adult stem cells
extracted from adult bone marrow can grow into neural stem cells, potentially
useful to repair damaged nerve cells in the spine and brain. ( CNN, August
15, 2000)
Also, a new procedure by an American subsidiary of the British Biotech company PPL Therapeutics, which takes and stores a few dozen millilitres of blood from the umbilical cord after birth, yields a rich source of stem cells. If the child develops a disease such as leukemia, the cells can be used to provide healthy blood, with no risk of rejection, and no ethical problems. Chief medical officer, Professor Liam Donaldson, called this ability to make a patient's own tissue without the ethical complications of destroying cloned embryos, the "Holy Grail". (Brisbane Sunday Mail report by Helen McCabe 4 March 2001)**
Corneal grafts grown from a patient's own stem cells will be trialled by eye surgeons for the first time in 2001. Tissue engineers from QUT have developed a way of growing new corneas in the laboratory, just like skin grafts. Researcher Damien Harkin, having spent 2 years perfecting the technique, will now trial taking a tiny piece of tissue from the patient's good eye, culturing it in the laboratory into a sheet of corneal cells, and grafting this onto the patient's other, damaged eye. The aim is to get a better compatibility than from donor grafts, and to heal inflammation in the damaged eye. (RockhamptonMorning Bulletin Aug 6th, 2001)
However, injection of foetal stem cells into the basal ganglia of Parkinsons
disease patients has had to be abandoned, as no patients showed improvement
and 15% of patients had muscular movements worsen due to the
stem cells (which cannot be removed or deactivated) growing too well and
producing excessive amounts of dopamine. (see
QRTL newsletter
April 2001) Quoting Columbia University neurologist Dr. Paul Green in the
New England Journal of Medicine, "The uncontrollable movements some patients
suffered were absolutely devastating. They chew constantly, their fingers
go up and down, and their wrists flex and distend. [The patients] writhe
and twist, jerk their heads, fling their arms about. It is tragic, catastrophic,
a real nightmare. And we cannot selectively turn it off." New England Journal
of Medicine, volume 344:710-719 March 8, 2001 Number
10 "Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease"
Curt R. Freed, M.D., Paul E. Greene, M.D., et. al., also Weber, W., Butcher,
J. (2001) `Doubts over cell therapy for Parkinson's disease', Lancet 357,
859, March 17.**
A more frightening story was reported in 1996 in the Journal Neurology.
Fetal tissue injected into a patient's brain produced transient improvement,
but within two years the patient developed a brain tumor and died. An autopsy
revealed that the fetal cells had taken root, but had then metamorphed into
other types of human tissue -- hair, skin and bone. These grew into the tumor,
which killed the patient. Folkerth, R.D., Durso, R. (1996) `Survival and
proliferation of non-neural tissues, with obstruction of cerebral ventricles,
in a Parkinsonian patient treated with fetal allografts', Neurology 46, 1219-25.
So far, all the "claims" made for use of fetal tissue are at best overpublicised "promises", hoped for results that have not been achieved.
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Stem Cell Research links: www.cogforlife Research using adult stem cells A German man has had his heart repaired after suffering a heart attack with stem cells taken from his own pelvis. see http://www.ananova.com/news/story/sm_382867.html
NIH guidelines misleading on adult stem cells
Pontifical Academy for Life declaration
CNN.com Health related articles: Vaccines and
Abortions and stem cells
Recycling babies: the
practice of fetal tissue research
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Research papers which clearly show adult stem cells successful versus
embryo stem cell research unsuccessful:
Paraplegic rats:
Ramon-Cueto (using adult nerve stem cells for paralised rats)
"Functional recovery of paraplegic rats and motor axon regeneration in their
spinal cords by olfactory ensheathing glia" Neuron 25, 425-435; Feb 2000
( this animal trial success has led to human trials of the same adult
nerve cells in spinal injury by Prof Peter Silburn and his team at Brisbane's
PA Hospital spinal unit in 2002.) compare this to similar study using
embryonic stem cells on rats:
Macdonald, JW et al. Nature Medicine 12, 1410-1412, Dec 1999 (proved slightly
better than no treatment at all, 1 in 5 incidence of tumours in rats
arising from the transplanted embryonic stem cells)
Diabetes trials:
Adult stem cells form insulin-secreting cells - Scientists
retrained immune cells to reverse type 1 diabetes in mice
S Ryu et al. "Reversal of established autoimmune diabetes by restoration
of endogenous B cell function," J Clin Invest 108, 63-72
In June another trial using liver stem cells completely reversed their diabetes
Yang L et al. "In vitro trans-differentiation of adult hepatic
stem cells into pancreatic endocrine hormone-producing cells" Proceedings
of National Academy of Sciences USA June 4 2002.(http://www.pnas.org/cgi/content/full/99/12/8078
)Human trials will soon occur after this success.
Embryonic stem cells secreted only 1/50th the normal amount of insulin
and the diabetic mice who received the implants died.
N Lumelsky et al. "Differentiation of embryonic stem cells to insulin-secreting
structures similar to pancreatic islets" Science 292. 1389-1394, May 18 2001.
**
Parkinsons Disease:
Adult stem cells
Chicago Rush Hospital team identified the signal to turn brain stem
cells into dopamine neurons, and grafted the cells into brains of Parkinsons
rats, effectively curing the rats' severe Parkinsons symptoms. Experimental
Biology meeting, New Orleans, April 2002
Emory University group implanted retinal cells into brains of advanced
Parkinsons patients, improving their motor function by 50% . American
Academy of Neurology Conference, Denver, April 18, 2002
Los Angeles Cedars-Sinai Medical Center reports a total reversal of
symptoms in the first Parkinsons patient treated using the patients' own
adult neural cells. American Association of Neurological Surgeons meeting,
April 8, 2002.
Australian trials are now planned.
Embryonic stem cells
Parkinsons rats injected with embryonic stem cells showed a modest benefit
for just over 50% of rats, but 20% died of brain tumours caused by these
stem cells. L M Bjorklund et al. "Embryonic stem cells develop into
functional dopamine neurons after transplantation in a Parkinson rat model"
Proc. Natl. Acad. Sci USA 99, 2344-2349, Feb 19 2002, published online Jan
8 2002.
More journal citations available on request by emailing afalist@family.org.au
and asking for copy of DO NO HARM Australians for ethical medical research
media release Thursday 29th August 2002 "Trounsen: more misleading rodents
revealed"
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opportunities for research. I have concluded that we should allow federal funds to be used for research on these existing stem cell lines, where the life-and-death decision has already been made. Leading scientists tell me research on these 60 lines has great promise that could lead to breakthrough therapies and cures. This allows us to explore the promise and potential of stem cell research without crossing a fundamental moral line by providing taxpayer funding that would sanction or encourage further destruction of human embryos that have at least the potential for life. I also believe that great scientific progress can be made through aggressive federal funding of research on umbilical cord, placenta, adult and animal stem cells, which do not involve the same moral dilemma. This year your government will spend $250 million on this important research." Reaction: 1.Bishop Joseph Fiorenza,
President of the U.S. Conference of Catholic Bishops - ``The trade-off he
has announced is morally unacceptable: The federal government, for the first
time in history, will support research that relies on the destruction of
some defenseless human beings for the possible benefit to others.'' 2.
American Life League analysis
SINGAPORE, Aug 14 (AFP) - UNITED KINGDOM Daily Telegraph, 18 September 2001 Clarke, D L Johansson, C B Frisen J et al. "Generalised potential of adult neural stem cells" Science 2000, 288, pp1600-1663. ** Vogel, G. "Can old cells learn new tricks?" Science 25 Feb 2000 p. 1418-1419 ** Hines, P Purnell, B Marx, J "Stem cells branch out" Science 25 Feb 2000 p. 1417 ** Hall, Stephen S. "Adult Stem Cells" Technology Review magazine November 2001 ** (http://www.technologyreview.com/magazine/nov01/hall.asp) |
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MARCH 2003
The bill was opposed on a conscience vote by 8 government MPs and 12 opposition
MPs. But 65 government, independent and Opposition MPs, including Opposition
leader Lawrence Springborg, ganged up to pass the law.
AYES, 65— Attwood, Barry, Barton, Beattie, Bligh, Boyle, Bredhauer,
Briskey, E. Clark, L. Clark, Croft,J. Cunningham, Edmond, English, Fenlon, Foley, Fouras, Hayward, Hobbs,
Jarratt, Keech, Lavarch, Lawlor, Lingard,Livingstone, Lucas, Mackenroth, Male, Malone, McGrady, McNamara, Miller,
Molloy, Mulherin, Nelson-Carr, Nolan,Nuttall, Palaszczuk, Pearce, Phillips, Poole, Quinn, Reilly, Reynolds, E.
Roberts, Robertson, Rodgers, Rose, Schwarten, C. Scott, D. Scott, Seeney, Sheldon, Spence, Stone, Strong,
Struthers, C. Sullivan, Welford, Watson,Welford, Wellington, Wells, Wilson. Tellers: Springborg, Reeves.
Queensland has become the first Australian state to authorize embryonic stem cell research using so-called "surplus" embryos from IVF clinics. Under the law, scientists will be able to experiment on all leftover embryonic humans created by IVF before April 5, 2002, with the sperm/ova donors' consent. NOES, 20— Bell, Choi, Copeland, E. Cunningham, Flynn, Horan, Johnson, Lee, Lee Long, Lester, Mickel, Pitt, Pratt, Purcell, Rowell, Shine, Simpson, Smith. Tellers: T. Sullivan, Hopper Labor backbencher Ronan Lee criticized the government for arguing that embryos are not important because they are "smaller than a full stop. We ought to look at them not as though they are worthless but with wonderment," Mr. Lee said. "We ought to treat them with respect." For local coverage: http://www.dailytelegraph.news.com.au/common/story_page/0,5936,6116787%255E1 702,00.html For related coverage: AUSTRALIA SET TO ALLOW DESTRUCTIVE RESEARCH ON HUMAN EMBRYOS http://www.lifesite.net/ldn/2002/apr/02040404.html 2002 After
a long,divisive national debate,Australia's Senate passed legislation
allowing researchers to harvest human embryos from IVF clinics for their
stem cells - and destroy them in the process. The Senate voted 45-26 in favor
of the Research Involving Embryos Bill,with members permitted to a rare conscience
vote on the issue. Kirsten Livermore
voted for the Bill, as did fellow Qld senators Bartlett, Cherry, Ludwig,
Mason, Moore, and McLucas. Against the Bill were Qld Senators Boswell, Brandis,
Hogg, and Santoro. The report of the Senate Commitee on Research involving embryos and prohibition of human cloning Bill 2002 has been posted on the internet at http://www.aph.gov.au/senate/committee/clac_ctte/emb_cloning/report/index.htm The report show that the Committee members themselves were split on the issues and unable to form a united opinion on the ethics of using human embryos for research. Some of the many public submissions to this Senate Commitee on Research involving embryos and prohibition of human cloning Bill 2002 can be viewed at http://www.aph.gov.au/Senate/committee/clac_ctte/emb_cloning/submissions/sublist.htm 1851 submissions were tabled and 1803 of these were opposed to the Bill. In spite of this, the 2nd reading vote during the week of 11th-15th Nov was 43 senators in favour, 26 against. Source: Cybercast News Service;
August 29, 2002 The vote late Thursday followed an agreement
by lawmakers to split the cloning ban component from broader legislation they
are considering, which would also legalize controversial research on human
embryos. The ban covers cloning of a human embryo
for whatever purpose, including so-called "therapeutic cloning" -- pro-lifers
prefer to call it "destructive cloning" -- that would allow cloning of an
embryo solely to provide stem cells. It's been an eventful week in Australia's
lower house of parliament, with the pro-embryonic research camp under fire.The
country's leading proponent of embryonic research, Prof. Alan Trounson, earlier
admitted having misled lawmakers and the public about hopeful research on
rats which he incorrectly said had involved embryonic stem Subject: Scientist Lies to Aussie
Lawmakers on Stem Cell Research
ACT NOW!!!
"Do No Harm Coalition" of pro-life groups asks that YOU urgently lobby your
politicians, An Open Letter to Australia’s Federal, State and Territory Governments Our community must determine appropriate standards for medical research involving human subjects.... Respect Life Office Catholic Diocese of Melbourne |
Quotable quotes:
Quote on experiments on embryos by Geneticist Jerome Lejeune:
"To accept the fact that after fertilisation has taken place, a new human
being comes into being, is no longer a matter of taste or of opinion. The
human nature of the human being from conception to old age is not a metaphysical
contention, it is plain experimental evidence...Why we should not experiment
on human beings is very simple: from all the genetic laws that we have tried
to summarise, we are entirely convinced that every embryo is, by itself,
a human being...I am a doctor. I have sworn the Hippocratic Oath which means
that we are at the service of our patients, that we will never procure something
which can kill an embryo... People would not have faith in a doctor who is
trying to heal and sometimes to kill with the other hand." Evidence to Senate
Select Committee on Human Embryo Experimentation.
"Usually, terrible things that are done with the excuse that progress requires them are not really progress at all, but just terrible things." American philosopher Russell Baker
"We have been a consumer society for so long that for us it seems right
to consume our unborn. This consumption is not, in the first instance, by
the disabled and the sick. Currently the main consumers work in the biotech
industry, who serve to profit both professionally and financially on the
tissues of these beings who have never been allowed to be born....People have
an uncanny ablility to justify actions incrementally...it is declared a waste
to let 'spare' embryos and foetal tissue go unused, and research using both
is promoted." Andrew Cameron, lecturer in ethics, Moore Theological College,
Sydney, in an article "Consuming our unborn is indefensible"
(Sydney Morning Herald 7/08/02)